| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit [1-973] |
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| Ligand | BDBM120816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF kinase assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 2.30±0.0 nM |
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| Comments | extracted |
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| Citation |  Zhou, S; Ren, J; Liu, M; Ren, L; Liu, Y; Gong, P Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents. Bioorg Chem57:30-42 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit [1-973] |
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| Name: | Mast/stem cell growth factor receptor Kit [1-973] |
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| Synonyms: | KIT | KIT_HUMAN | Proto-oncogene c-Kit (c-Kit) | SCFR |
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| Type: | Protein |
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| Mol. Mass.: | 109542.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10721[1-973] |
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| Residue: | 973 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVH
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| BDBM120816 |
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| n/a |
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| Name | BDBM120816 |
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| Synonyms: | (Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy) quinolin-4-yl)oxy)phenyl)amino)methylene)-3-methyl-1-(2- (trifluoromethyl)phenyl)-1H-pyrazol-5(4H)-one (17) |
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| Type | Small organic molecule |
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| Emp. Form. | C35H33F4N5O5 |
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| Mol. Mass. | 679.6606 |
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| SMILES | COc1cc2c(Oc3ccc(cc3F)N=Cc3c(C)[nH]n(-c4ccccc4C(F)(F)F)c3=O)ccnc2cc1OCCCN1CCOCC1 |w:14.14| |
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| Structure | 
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