| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylmuramate--L-alanine ligase |
|---|
| Ligand | BDBM123106 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | P. aeruginosa MurC assay |
|---|
| Temperature | 298.15±0 K |
|---|
| IC50 | 1e+1±n/a nM |
|---|
| Citation |  Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylmuramate--L-alanine ligase |
|---|
| Name: | UDP-N-acetylmuramate--L-alanine ligase |
|---|
| Synonyms: | MURC_PSEAE | MurC (P. aeruginosa) | murC |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51977.96 |
|---|
| Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
|---|
| Description: | Q9HW02 |
|---|
| Residue: | 480 |
|---|
| Sequence: | MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFG
AQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAV
AGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLH
LQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIA
RPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIA
TDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGG
WPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSI
RQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
|
|
|
|---|
| BDBM123106 |
|---|
| n/a |
|---|
| Name | BDBM123106 |
|---|
| Synonyms: | (R)-2-cyclohexyl-2-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)ethanol (5) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30N8O |
|---|
| Mol. Mass. | 398.5052 |
|---|
| SMILES | CC(C)(C)c1cc(Nc2nc(NC(CO)C3CCCCC3)nc3n[nH]cc23)[nH]n1 |
|---|
| Structure | 
|
|---|
Search and Browse
