Reaction Details |
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Target | UDP-N-acetylmuramate--L-alanine ligase |
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Ligand | BDBM123117 |
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Substrate/Competitor | n/a |
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Meas. Tech. | E.coli MurC assay |
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Temperature | 298.15±0 K |
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IC50 | 21±n/a nM |
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Citation | Hameed P, S; Manjrekar, P; Chinnapattu, M; Humnabadkar, V; Shanbhag, G; Kedari, C; Mudugal, NV; Ambady, A; de Jonge, BL; Sadler, C; Paul, B; Sriram, S; Kaur, P; Guptha, S; Raichurkar, A; Fleming, P; Eyermann, CJ; McKinney, DC; Sambandamurthy, VK; Panda, M; Ravishankar, S Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli. ACS Chem Biol9:2274-82 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylmuramate--L-alanine ligase |
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Name: | UDP-N-acetylmuramate--L-alanine ligase |
Synonyms: | MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC |
Type: | Protein |
Mol. Mass.: | 53617.78 |
Organism: | Escherichia coli |
Description: | P17952 |
Residue: | 491 |
Sequence: | MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
MNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAA
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
DSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD
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BDBM123117 |
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n/a |
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Name | BDBM123117 |
Synonyms: | (R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-2-(4-methoxyphenyl)ethanol (16) |
Type | Small organic molecule |
Emp. Form. | C22H28N8O2 |
Mol. Mass. | 436.5101 |
SMILES | COc1ccc(cc1)[C@H](CO)Nc1nc(Nc2cc(n(C)n2)C(C)(C)C)c2c[nH]nc2n1 |
Structure |
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