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TargetProstaglandin D Synthase
LigandBDBM124919
Substrate/Competitorn/a
Meas. Tech.Inhibiting Action
pH8±n/a
IC50 31±n/a nM
Commentsextracted
Citation Urade YKitade MShigeno KYamane KTanaka K Piperazine compound having a PGDS inhibitory effect US Patent  US8765750 Publication Date 7/1/2014
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM124919
n/a
NameBDBM124919
Synonyms:US8765750, 4
TypeSmall organic molecule
Emp. Form.C28H37N5O4
Mol. Mass.507.6245
SMILESCC1C=CC=C1C(=O)N1CCN(CC1)C(=O)NC1CCN(CC1)c1ccc(cc1)C(=O)N1CCOCC1 |c:2,4|
Structure
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