Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM124933 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibiting Action |
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pH | 8±n/a |
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IC50 | 445±n/a nM |
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Comments | extracted |
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Citation | Urade, Y; Kitade, M; Shigeno, K; Yamane, K; Tanaka, K Piperazine compound having a PGDS inhibitory effect US Patent US8765750 Publication Date 7/1/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM124933 |
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n/a |
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Name | BDBM124933 |
Synonyms: | US8765750, Reference Example 6 |
Type | Small organic molecule |
Emp. Form. | C28H38N6O5 |
Mol. Mass. | 538.6385 |
SMILES | O=C(NC1CCN(CC1)c1ccc(cc1)C(=O)NCCN1CCOCC1)N1CCN(CC1)C(=O)c1ccco1 |
Structure |
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