Ki Summary

Reaction Details

Report a problem with these data

Target

Cyclin-T1

Ligand

BDBM126473

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.001±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126473

n/a

Name

BDBM126473

Synonyms:

US8778951, 283

Type

Small organic molecule

Emp. Form.

C25H35ClFN5O2

Mol. Mass.

492.029

SMILES

COCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1F |r,wU:8.11,wD:5.4,(7.64,1.68,;6.3,2.45,;4.97,1.68,;3.63,2.45,;2.3,1.68,;.97,2.45,;.97,3.99,;-.37,4.76,;-1.7,3.99,;-1.7,2.45,;-.37,1.68,;-3.03,4.76,;-4.37,3.99,;-4.37,2.45,;-5.7,1.68,;-7.04,2.45,;-8.37,1.68,;-7.04,3.99,;-5.7,4.76,;-5.7,.14,;-4.37,-.63,;-4.37,-2.17,;-3.03,-2.94,;-1.7,-2.17,;-.37,-2.94,;-.37,-4.48,;.97,-5.25,;2.3,-4.48,;2.3,-2.94,;.97,-2.17,;-5.7,-2.94,;-7.04,-2.17,;-7.04,-.63,;-8.37,.14,)|

Structure