Ki Summary

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Target

Cyclin-T1

Ligand

BDBM126532

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.00031±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126532

n/a

Name

BDBM126532

Synonyms:

US8778951, 343

Type

Small organic molecule

Emp. Form.

C29H40ClFN6O

Mol. Mass.

543.119

SMILES

CCCN(CCC)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 |r,wU:10.13,wD:7.6,(7.02,2.45,;5.69,1.68,;4.36,2.45,;3.02,1.68,;3.02,.14,;4.36,-.63,;5.13,-1.97,;1.69,2.45,;1.69,3.99,;.35,4.76,;-.98,3.99,;-.98,2.45,;.35,1.68,;-2.31,4.76,;-3.65,3.99,;-3.65,2.45,;-4.98,1.68,;-6.31,2.45,;-7.65,1.68,;-6.31,3.99,;-4.98,4.76,;-4.98,.14,;-6.31,-.63,;-6.31,-2.17,;-4.98,-2.94,;-4.98,-4.48,;-3.65,-2.17,;-2.31,-2.94,;-.98,-2.17,;.35,-2.94,;.35,-4.48,;1.69,-5.25,;3.02,-4.48,;3.02,-2.94,;1.69,-2.17,;.35,-1.4,;.35,.14,;-3.65,-.63,)|

Structure