Ki Summary

Reaction Details

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Target

Cyclin-T1

Ligand

BDBM126550

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.0003±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126550

n/a

Name

BDBM126550

Synonyms:

US8778951, 361

Type

Small organic molecule

Emp. Form.

C25H33ClN6O

Mol. Mass.

469.022

SMILES

CN(C)[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 |r,wU:6.9,wD:3.2,(6,2.7,;4.67,1.93,;4.67,.39,;3.33,2.7,;3.33,4.24,;2,5,;.67,4.24,;.67,2.7,;2,1.93,;-.67,5.01,;-2,4.23,;-2,2.69,;-3.33,1.92,;-4.67,2.69,;-6,1.92,;-4.67,4.23,;-3.33,5,;-3.33,.38,;-4.67,-.39,;-4.67,-1.93,;-3.33,-2.7,;-2,-1.93,;-.67,-2.7,;.67,-1.93,;2,-2.7,;2,-4.24,;3.33,-5.01,;4.67,-4.24,;4.67,-2.7,;3.33,-1.93,;2,-1.16,;2,.38,;-2,-.39,)|

Structure