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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
| Ligand | BDBM127894 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Lanthascreen Binding Assay | ||
| Ki | 3±n/a nM | ||
| Citation |  Baker-Glenn, C; Chambers, M; Chan, BK; Estrada, A; Sweeney, ZK Aminopyrimidine derivatives as LRRK2 modulators US Patent US8791130 Publication Date 7/29/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Leucine-rich repeat serine/threonine-protein kinase 2 | |||
| Name: | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
| Synonyms: | Dardarin | LRRK2 | LRRK2_HUMAN | Leucine-Rich Repeat Kinase 2 Protein (LRRK2) | Leucine-rich repeat serine/threonine-protein kinase 2 | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) | PARK8 | ||
| Type: | Protein | ||
| Mol. Mass.: | 286113.20 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q5S007 | ||
| Residue: | 2527 | ||
| Sequence: |
| ||
| BDBM127894 | |||
| n/a | |||
| Name | BDBM127894 | ||
| Synonyms: | US8791130, 24 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H20ClF3N6O | ||
| Mol. Mass. | 440.85 | ||
| SMILES | CNc1nc(Nc2cc(OC)c(cc2Cl)-c2c(C)nn(C)c2C)ncc1C(F)(F)F |(-1.75,2.87,;-3.08,2.1,;-3.08,.56,;-1.75,-.21,;-1.75,-1.75,;-.41,-2.52,;.92,-1.75,;.92,-.21,;2.25,.56,;2.25,2.1,;.92,2.87,;3.59,-.21,;3.59,-1.75,;2.25,-2.52,;2.25,-4.06,;4.92,.56,;6.38,.08,;6.78,-1.41,;7.29,1.33,;6.38,2.57,;6.78,4.06,;4.92,2.1,;3.59,2.87,;-3.08,-2.52,;-4.42,-1.75,;-4.42,-.21,;-5.75,.56,;-7.29,.56,;-5.75,2.1,;-6.52,-.78,)| | ||
| Structure | 
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