| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50123973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Histone Deacetylase Enzymatic Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 480±n/a nM |
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| Comments | extracted |
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| Citation |  Déziel, R; Ajamian, A Inhibitors of histone deacetylase and prodrugs thereof US Patent US8796330 Publication Date 8/5/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
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| BDBM50123973 |
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| n/a |
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| Name | BDBM50123973 |
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| Synonyms: | 3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-hydroxy-acrylamide | CHEMBL148769 | US8796330, 147 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N3O5 |
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| Mol. Mass. | 357.3606 |
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| SMILES | COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC |
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| Structure | 
|
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