| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM4749 |
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| Substrate/Competitor | BDBM4702 |
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| Meas. Tech. | Neuraminidase Inhibition Assay |
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| IC50 | 12500±n/a nM |
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| Citation |  Chand, P; Babu, YS; Bantia, S; Rowland, S; Dehghani, A; Kotian, PL; Hutchison, TL; Ali, S; Brouillette, W; El-Kattan, Y; Lin, TH Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives. J Med Chem47:1919-29 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | Influenza B Virus Neuraminidase | NA | NRAM_INBLE | Neuraminidase | Neuraminidase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51446.67 |
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| Organism: | Influenza B virus (B/Lee/40) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MLPSTVQTLTLLLTSGGVLLSLYVSASLSYLLYSDVLLKFSSTKTTAPTMSLECTNASNA
QTVNHSATKEMTFPPPEPEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFV
ACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAWSGS
ACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMI
TDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEECTCGFASNKTIECACRDNSYTAKR
PFVKLNVETDTAEIRLMCTKTYLDTPRPDDGSIAGPCESNGDKWLGGIKGGFVHQRMASK
IGRWYSRTMSKTNRMGMELYVKYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKC
DVPCIGIEMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
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| BDBM4749 |
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| BDBM4702 |
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| Name | BDBM4749 |
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| Synonyms: | (3S,4S)-3-carbamimidamido-4-[(S)-acetamido[(4-phenylbutan-2-yl)carbamoyl]methyl]cyclopentane-1-carboxylic acid | Cyclopentane Amide deriv. 14l |
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| Type | Small organic molecule |
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| Emp. Form. | C21H31N5O4 |
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| Mol. Mass. | 417.5019 |
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| SMILES | [#6]-[#6](-[#6]-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6](-[#7]-[#6](-[#6])=O)-[#6@H]-1-[#6]-[#6](-[#6]-[#6@@H]-1\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O |r,w:20.28,13.14| |
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| Structure | 
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