Reaction Details | |||
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Target | Fibroblast growth factor receptor 3 | ||
Ligand | BDBM130078 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | LanthaScreen TR-FRET Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 11±n/a nM | ||
Comments | extracted | ||
Citation | Furet, P; Graus Porta, D; Guagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent US8815901 Publication Date 8/26/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fibroblast growth factor receptor 3 | |||
Name: | Fibroblast growth factor receptor 3 | ||
Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 | ||
Type: | Protein | ||
Mol. Mass.: | 87699.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P22607 | ||
Residue: | 806 | ||
Sequence: |
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BDBM130078 | |||
n/a | |||
Name | BDBM130078 | ||
Synonyms: | US8815901, 135 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H24F2N6O4 | ||
Mol. Mass. | 510.4927 | ||
SMILES | COc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCOCC3)[nH]2)c2nccnc12 |(10.4,-2.67,;8.86,-2.67,;8.09,-1.33,;8.86,,;8.09,1.33,;8.86,2.67,;8.09,4,;6.55,1.33,;5.78,2.67,;5.78,,;6.55,-1.33,;5.78,-2.67,;4.24,,;3.47,1.33,;1.93,1.33,;1.16,,;-.38,,;-1.15,1.33,;-1.15,-1.33,;-2.69,-1.33,;-3.6,-.09,;-5.06,-.56,;-5.06,-2.1,;-6.4,-2.87,;-7.73,-2.1,;-7.73,-.56,;-9.06,.21,;-10.4,-.56,;-10.4,-2.1,;-9.06,-2.87,;-3.6,-2.58,;1.93,-1.33,;1.16,-2.67,;1.93,-4,;3.47,-4,;4.24,-2.67,;3.47,-1.33,)| | ||
Structure |