| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
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| Ligand | BDBM130383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Spectral Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Kd | 393± 24 nM |
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| Comments | extracted |
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| Citation |  Li, H; Jamal, J; Delker, S; Plaza, C; Ji, H; Jing, Q; Huang, H; Kang, S; Silverman, RB; Poulos, TL The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry53:5272-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
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| Name: | Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
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| Synonyms: | Bnos | NOS1_RAT | Neuronal nitric oxide synthase mutant (D597N/M336V) | Nitric oxide synthase mutant (nNOS M336V/D597N) | Nitric oxide synthase, brain (PNNOS) [1-973,I269V,M336V,D597N] | Nos1 |
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| Type: | Protein |
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| Mol. Mass.: | 108435.83 |
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| Organism: | Rattus norvegicus (rats) |
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| Description: | Rat neuronal nitric oxide synthase mutant M336V/D597N |
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| Residue: | 973 |
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| Sequence: | MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAI
DPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLD
GKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSEKEQSPTSGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIVLPSQHTRKPEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRNYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKY
PEPLRFFPRKGPSLSHVDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRD
NFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEA
FRTWAKKVFKAAC
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| BDBM130383 |
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| n/a |
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| Name | BDBM130383 |
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| Synonyms: | 4methyl6{[(3R,4R)4{[5(4methylpyridin2 yl)pentyl]oxy}pyrrolidin3yl]methyl}pyridin2amine ((3R,4R)-3) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H32N4O |
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| Mol. Mass. | 368.5157 |
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| SMILES | Cc1ccnc(CCCCCO[C@H]2CNC[C@H]2Cc2cc(C)cc(N)n2)c1 |r| |
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| Structure | 
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