| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled receptor 6 |
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| Ligand | BDBM191017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of cAMP Activity of GPR6 In Vitro A.1 Assay |
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| IC50 | 62000±n/a nM |
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| Citation |  Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent US10077266 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled receptor 6 |
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| Name: | G-protein coupled receptor 6 |
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| Synonyms: | G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6 |
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| Type: | Protein |
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| Mol. Mass.: | 37886.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46095 |
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| Residue: | 362 |
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| Sequence: | MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
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| BDBM191017 |
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| n/a |
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| Name | BDBM191017 |
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| Synonyms: | US10077266, Example 129 | US9181249, 129 | US9708313, 129 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31F2N5O2 |
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| Mol. Mass. | 459.532 |
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| SMILES | CC[C@H](C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O |r| |
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| Structure | 
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