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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131865 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 214±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131865 | |||
| n/a | |||
| Name | BDBM131865 | ||
| Synonyms: | US8835444, 2.14 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23ClF3N3O | ||
| Mol. Mass. | 413.864 | ||
| SMILES | Cc1cnn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)c1C |r,wU:6.5,wD:9.12,(8.38,-1.42,;7.61,-.09,;8.52,1.15,;7.61,2.4,;6.15,1.93,;4.82,2.69,;3.48,1.93,;3.48,.38,;2.15,-.38,;.82,.38,;.82,1.93,;2.15,2.69,;-.52,-.38,;-1.85,.38,;-1.85,1.93,;-3.19,-.38,;-4.52,.38,;-5.85,-.38,;-5.85,-1.93,;-4.52,-2.69,;-3.19,-1.93,;-1.85,-2.69,;-7.19,.38,;-8.52,-.38,;-7.19,1.93,;-8.52,1.15,;6.15,.38,;4.82,-.38,)| | ||
| Structure | 
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