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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131866 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 170±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM131866 | |||
| n/a | |||
| Name | BDBM131866 | ||
| Synonyms: | US8835444, 2.15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23ClF3N3O | ||
| Mol. Mass. | 425.875 | ||
| SMILES | FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2ncc3CCCc23)CC1 |r,wU:17.18,wD:14.14,(-8.58,-.45,;-7.25,.32,;-7.25,1.86,;-8.58,1.09,;-5.91,-.45,;-5.91,-1.99,;-4.58,-2.76,;-3.25,-1.99,;-1.91,-2.76,;-3.25,-.45,;-4.58,.32,;-1.91,.32,;-1.91,1.86,;-.58,-.45,;.75,.32,;2.09,-.45,;3.42,.32,;3.42,1.86,;4.76,2.63,;6.09,1.86,;7.34,2.76,;8.58,1.86,;8.11,.39,;8.58,-1.07,;7.34,-1.98,;6.09,-1.07,;6.57,.39,;2.09,2.63,;.75,1.86,)| | ||
| Structure | 
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