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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131867 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 147±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM131867 | |||
| n/a | |||
| Name | BDBM131867 | ||
| Synonyms: | US8835444, 2.16 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23ClF3N3O | ||
| Mol. Mass. | 425.875 | ||
| SMILES | FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2cc3CCCc3n2)CC1 |r,wU:17.18,wD:14.14,(-8.97,-.39,;-7.63,.38,;-7.63,1.92,;-8.97,1.15,;-6.3,-.39,;-6.3,-1.93,;-4.97,-2.7,;-3.63,-1.93,;-2.3,-2.7,;-3.63,-.39,;-4.97,.38,;-2.3,.38,;-2.3,1.92,;-.96,-.39,;.37,.38,;1.7,-.39,;3.04,.38,;3.04,1.92,;4.37,2.7,;5.7,1.92,;7.24,1.92,;7.72,.46,;8.97,-.44,;8.49,-1.91,;6.95,-1.91,;6.47,-.44,;5.23,.46,;1.7,2.7,;.37,1.92,)| | ||
| Structure | 
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