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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131862 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 318±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131862 | |||
| n/a | |||
| Name | BDBM131862 | ||
| Synonyms: | US8835444, 2.3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H27ClN4O | ||
| Mol. Mass. | 386.918 | ||
| SMILES | Cc1ncc(Cl)cc1C(=O)N[C@H]1CC[C@H](Cn2cc3CCCCc3n2)CC1 |r,wU:14.15,wD:11.11,(-3.71,-2.69,;-5.04,-1.93,;-6.37,-2.69,;-7.71,-1.93,;-7.71,-.38,;-9.04,.38,;-6.37,.38,;-5.04,-.38,;-3.71,.38,;-3.71,1.93,;-2.37,-.38,;-1.04,.38,;.29,-.38,;1.63,.38,;1.63,1.93,;2.96,2.69,;4.29,1.93,;4.46,.39,;5.96,.07,;6.73,-1.26,;8.27,-1.26,;9.04,.07,;8.27,1.41,;6.73,1.41,;5.7,2.55,;.29,2.69,;-1.04,1.93,)| | ||
| Structure | 
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