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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131872 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 59±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131872 | |||
| n/a | |||
| Name | BDBM131872 | ||
| Synonyms: | US8835444, 4.2 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H25ClF3N3O3 | ||
| Mol. Mass. | 519.943 | ||
| SMILES | Cc1cc(nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(ccc1Cl)C(F)(F)F)-c1ccc2OCOc2c1 |r,wU:7.7,wD:10.14,(4.91,4.22,;4.91,2.68,;6.16,1.77,;5.68,.31,;4.14,.31,;3.67,1.77,;2.33,2.54,;1,1.77,;1,.23,;-.34,-.54,;-1.67,.23,;-1.67,1.77,;-.34,2.54,;-3,-.54,;-4.34,.23,;-4.34,1.77,;-5.67,-.54,;-7,.23,;-8.34,-.54,;-8.34,-2.08,;-7,-2.85,;-5.67,-2.08,;-4.34,-2.85,;-9.67,.23,;-11,-.54,;-9.67,1.77,;-11,1,;6.45,-1.02,;5.98,-2.49,;7.01,-3.63,;8.51,-3.31,;9.76,-4.22,;11,-3.31,;10.53,-1.85,;8.99,-1.85,;7.96,-.7,)| | ||
| Structure | 
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