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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131873 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 6956±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131873 | |||
| n/a | |||
| Name | BDBM131873 | ||
| Synonyms: | US8835444, 4.4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H25ClN4O2 | ||
| Mol. Mass. | 376.88 | ||
| SMILES | Cc1cc(CO)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)n1 |r,wU:8.7,wD:11.14,(8.63,1.15,;7.09,1.15,;6.19,-.09,;4.72,.38,;3.63,-.7,;4.03,-2.19,;4.71,1.93,;3.37,2.69,;2.04,1.93,;2.04,.38,;.7,-.38,;-.63,.38,;-.63,1.93,;.7,2.69,;-1.96,-.38,;-3.3,.38,;-3.3,1.93,;-4.63,-.38,;-5.96,.38,;-7.3,-.38,;-8.63,.38,;-7.3,-1.93,;-5.96,-2.69,;-4.63,-1.93,;-3.3,-2.69,;6.19,2.4,)| | ||
| Structure | 
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