Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131875 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 40±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM131875 | |||
| n/a | |||
| Name | BDBM131875 | ||
| Synonyms: | US8835444, 4.6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H29ClN4O | ||
| Mol. Mass. | 388.934 | ||
| SMILES | CC(C)c1cc(C)nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C |r,wU:10.10,wD:13.17,(4.54,-2.18,;4.14,-.7,;2.66,-.3,;5.23,.39,;6.77,.39,;7.25,1.86,;8.58,2.63,;6,2.76,;4.76,1.86,;3.42,2.63,;2.09,1.86,;2.09,.32,;.75,-.45,;-.58,.32,;-.58,1.86,;.75,2.63,;-1.91,-.45,;-3.25,.32,;-3.25,1.86,;-4.58,-.45,;-5.91,.32,;-7.25,-.45,;-8.58,.32,;-7.25,-1.99,;-5.91,-2.76,;-4.58,-1.99,;-3.25,-2.76,)| | ||
| Structure | 
| ||