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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131879 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 132±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131879 | |||
| n/a | |||
| Name | BDBM131879 | ||
| Synonyms: | US8835444, 5.17 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21ClF3N3O | ||
| Mol. Mass. | 399.838 | ||
| SMILES | Cc1cnn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)c1 |r,wU:6.5,wD:9.12,(8.73,-.94,;7.96,.39,;8.43,1.86,;7.19,2.76,;5.94,1.86,;4.61,2.63,;3.27,1.86,;3.27,.32,;1.94,-.45,;.61,.32,;.61,1.86,;1.94,2.63,;-.73,-.45,;-2.06,.32,;-2.06,1.86,;-3.39,-.45,;-4.73,.32,;-6.06,-.45,;-6.06,-1.99,;-4.73,-2.76,;-3.39,-1.99,;-2.06,-2.76,;-7.39,.32,;-7.39,1.86,;-8.73,-.45,;-8.73,1.09,;6.42,.39,)| | ||
| Structure | 
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