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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131877 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 126±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131877 | |||
| n/a | |||
| Name | BDBM131877 | ||
| Synonyms: | US8835444, 5.8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23ClF3N3O2 | ||
| Mol. Mass. | 429.864 | ||
| SMILES | COc1cc(C)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)n1 |r,wU:8.7,wD:11.14,(9.52,3.25,;9.13,1.77,;7.64,1.37,;7.16,-.1,;5.62,-.1,;4.85,-1.43,;5.15,1.37,;3.81,2.14,;2.48,1.37,;2.48,-.17,;1.15,-.94,;-.19,-.17,;-.19,1.37,;1.15,2.14,;-1.52,-.94,;-2.86,-.17,;-2.86,1.37,;-4.19,-.94,;-5.52,-.17,;-6.86,-.94,;-6.86,-2.48,;-5.52,-3.25,;-4.19,-2.48,;-2.86,-3.25,;-8.19,-.17,;-8.19,1.37,;-9.52,-.94,;-9.52,.6,;6.39,2.27,)| | ||
| Structure | 
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