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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131860 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 35±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131860 | |||
| n/a | |||
| Name | BDBM131860 | ||
| Synonyms: | US8835444, 1.8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27Cl2F3N4O2 | ||
| Mol. Mass. | 555.419 | ||
| SMILES | COc1ccc(-c2c(C)[nH]nc2NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)c(Cl)c1 |r,wU:14.14,wD:17.21,(5.96,-4.65,;7.29,-3.88,;7.29,-2.34,;5.96,-1.57,;5.96,-.03,;7.29,.74,;7.29,2.28,;8.54,3.19,;9.87,2.42,;8.06,4.65,;6.52,4.65,;6.05,3.19,;4.71,2.42,;3.38,3.19,;2.04,2.42,;2.04,.88,;.71,.11,;-.62,.88,;-.62,2.42,;.71,3.19,;-1.96,.11,;-3.29,.88,;-3.29,2.42,;-4.62,.11,;-5.96,.88,;-7.29,.11,;-7.29,-1.43,;-5.96,-2.2,;-4.62,-1.43,;-3.29,-2.2,;-8.62,.88,;-9.96,.11,;-8.62,2.42,;-7.29,1.65,;8.62,-.03,;9.96,.74,;8.62,-1.57,)| | ||
| Structure | 
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