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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM131863 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 131±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM131863 | |||
| n/a | |||
| Name | BDBM131863 | ||
| Synonyms: | US8835444, 2.4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27ClN4O | ||
| Mol. Mass. | 422.95 | ||
| SMILES | Cc1cc(nn1C[C@H]1CC[C@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1ccccc1 |r,wU:10.14,7.7,(1.84,-.38,;3.17,.38,;4.64,-.09,;5.54,1.15,;4.64,2.4,;3.17,1.93,;1.84,2.69,;.51,1.93,;.51,.38,;-.83,-.38,;-2.16,.38,;-2.16,1.93,;-.83,2.69,;-3.49,-.38,;-4.83,.38,;-4.83,1.93,;-6.16,-.38,;-7.5,.38,;-8.83,-.38,;-10.16,.38,;-8.83,-1.93,;-7.5,-2.69,;-6.16,-1.93,;-4.83,-2.69,;7.08,1.15,;7.85,-.18,;9.39,-.18,;10.16,1.15,;9.39,2.49,;7.85,2.49,)| | ||
| Structure | 
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