Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM131869 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
IC50 | 142±n/a nM | ||
Citation | Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
| ||
BDBM131869 | |||
n/a | |||
Name | BDBM131869 | ||
Synonyms: | US8835444, 3.6 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H26ClN5O | ||
Mol. Mass. | 423.938 | ||
SMILES | Cc1cc(nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1cccnc1 |r,wU:7.7,wD:10.14,(2,-.38,;3.33,.38,;4.67,-.39,;6,.38,;6,1.93,;3.33,1.93,;2,2.69,;.67,1.93,;.67,.38,;-.67,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,-.38,;-4.67,.38,;-4.67,1.93,;-6,-.38,;-7.34,.38,;-8.67,-.38,;-10,.38,;-8.67,-1.93,;-7.34,-2.69,;-6,-1.93,;-4.67,-2.69,;7.34,-.38,;7.34,-1.93,;8.67,-2.69,;10,-1.93,;10,-.38,;8.67,.38,)| | ||
Structure |