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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 2 | ||
| Ligand | BDBM131858 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 4878±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 2 | |||
| Name: | Corticotropin-releasing factor receptor 2 | ||
| Synonyms: | CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 47694.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13324 | ||
| Residue: | 411 | ||
| Sequence: |
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| BDBM131858 | |||
| n/a | |||
| Name | BDBM131858 | ||
| Synonyms: | US8835444, 1.1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H28ClN5O | ||
| Mol. Mass. | 389.922 | ||
| SMILES | CCc1[nH]nc(NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)c1C |r,wU:11.14,wD:8.7,(9.52,.08,;9.13,1.56,;7.64,1.96,;7.16,3.43,;5.62,3.43,;5.15,1.96,;3.81,1.19,;2.48,1.96,;1.15,1.19,;-.19,1.96,;-1.52,1.19,;-1.52,-.35,;-.19,-1.12,;1.15,-.35,;-2.86,-1.12,;-4.19,-.35,;-4.19,1.19,;-5.52,-1.12,;-6.86,-.35,;-8.19,-1.12,;-9.52,-.35,;-8.19,-2.66,;-6.86,-3.43,;-5.52,-2.66,;-4.19,-3.43,;6.39,1.06,;6.39,-.48,)| | ||
| Structure | 
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