Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 2

Ligand

BDBM131863

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence Assay

IC50

4943±n/a nM

Citation

Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 2

Name:

Corticotropin-releasing factor receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

47694.70

Organism:

Homo sapiens (Human)

Description:

Q13324

Residue:

411

Sequence:

MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV

BDBM131863

n/a

Name

BDBM131863

Synonyms:

US8835444, 2.4

Type

Small organic molecule

Emp. Form.

C24H27ClN4O

Mol. Mass.

422.95

SMILES

Cc1cc(nn1C[C@H]1CC[C@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1ccccc1 |r,wU:10.14,7.7,(1.84,-.38,;3.17,.38,;4.64,-.09,;5.54,1.15,;4.64,2.4,;3.17,1.93,;1.84,2.69,;.51,1.93,;.51,.38,;-.83,-.38,;-2.16,.38,;-2.16,1.93,;-.83,2.69,;-3.49,-.38,;-4.83,.38,;-4.83,1.93,;-6.16,-.38,;-7.5,.38,;-8.83,-.38,;-10.16,.38,;-8.83,-1.93,;-7.5,-2.69,;-6.16,-1.93,;-4.83,-2.69,;7.08,1.15,;7.85,-.18,;9.39,-.18,;10.16,1.15,;9.39,2.49,;7.85,2.49,)|

Structure