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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 2 | ||
| Ligand | BDBM131880 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay | ||
| IC50 | 4847±n/a nM | ||
| Citation |  Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 2 | |||
| Name: | Corticotropin-releasing factor receptor 2 | ||
| Synonyms: | CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 47694.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13324 | ||
| Residue: | 411 | ||
| Sequence: |
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| BDBM131880 | |||
| n/a | |||
| Name | BDBM131880 | ||
| Synonyms: | US8835444, 5.21 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H20Cl2F3N3O2 | ||
| Mol. Mass. | 450.282 | ||
| SMILES | OCc1nn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)cc1Cl |r,wU:6.5,wD:9.12,(7.44,-2.27,;8.21,-.94,;7.44,.39,;5.9,.39,;5.42,1.86,;4.09,2.63,;2.76,1.86,;2.76,.32,;1.42,-.45,;.09,.32,;.09,1.86,;1.42,2.63,;-1.25,-.45,;-2.58,.32,;-2.58,1.86,;-3.91,-.45,;-5.25,.32,;-6.58,-.45,;-6.58,-1.99,;-5.25,-2.76,;-3.91,-1.99,;-2.58,-2.76,;-7.91,.32,;-7.91,1.86,;-9.25,-.45,;-9.25,1.09,;6.67,2.76,;7.91,1.86,;9.25,2.63,)| | ||
| Structure | 
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