Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 2

Ligand

BDBM131868

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence Assay

IC50

4630±n/a nM

Citation

Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 2

Name:

Corticotropin-releasing factor receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

47694.70

Organism:

Homo sapiens (Human)

Description:

Q13324

Residue:

411

Sequence:

MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV

BDBM131868

n/a

Name

BDBM131868

Synonyms:

US8835444, 3.3

Type

Small organic molecule

Emp. Form.

C24H26ClFN4O

Mol. Mass.

440.941

SMILES

Cc1cc(nn1C[C@H]1CC[C@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1ccc(F)cc1 |r,wU:10.14,7.7,(1.07,-.38,;2.4,.38,;3.87,-.09,;4.77,1.15,;3.87,2.4,;2.4,1.93,;1.07,2.69,;-.26,1.93,;-.26,.38,;-1.6,-.38,;-2.93,.38,;-2.93,1.93,;-1.6,2.69,;-4.26,-.38,;-5.6,.38,;-5.6,1.93,;-6.93,-.38,;-8.27,.38,;-9.6,-.38,;-10.93,.38,;-9.6,-1.93,;-8.27,-2.69,;-6.93,-1.93,;-5.6,-2.69,;6.31,1.15,;7.08,-.18,;8.62,-.18,;9.39,1.15,;10.93,1.15,;8.62,2.49,;7.08,2.49,)|

Structure