Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 2

Ligand

BDBM131869

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence Assay

IC50

3737±n/a nM

Citation

Beattie, D; Bruce, I; Colson, A; Culshaw, AJ; Sharp, T Cyclohexyl amide derivatives as CRF receptor antagonists US Patent US8835444 Publication Date 9/16/2014

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 2

Name:

Corticotropin-releasing factor receptor 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

47694.70

Organism:

Homo sapiens (Human)

Description:

Q13324

Residue:

411

Sequence:

MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV

BDBM131869

n/a

Name

BDBM131869

Synonyms:

US8835444, 3.6

Type

Small organic molecule

Emp. Form.

C23H26ClN5O

Mol. Mass.

423.938

SMILES

Cc1cc(nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1cccnc1 |r,wU:7.7,wD:10.14,(2,-.38,;3.33,.38,;4.67,-.39,;6,.38,;6,1.93,;3.33,1.93,;2,2.69,;.67,1.93,;.67,.38,;-.67,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,-.38,;-4.67,.38,;-4.67,1.93,;-6,-.38,;-7.34,.38,;-8.67,-.38,;-10,.38,;-8.67,-1.93,;-7.34,-2.69,;-6,-1.93,;-4.67,-2.69,;7.34,-.38,;7.34,-1.93,;8.67,-2.69,;10,-1.93,;10,-.38,;8.67,.38,)|

Structure