| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM285571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
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| IC50 | 3.92±n/a nM |
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| Citation |  Chappie TA; Patel NC; Hayward MM; Helal CJ; Sciabola S; LaChapelle EA; Young JM; Verhoest PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Synonyms: | PDE4B1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70253.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 615 |
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| Sequence: | ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT
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| BDBM285571 |
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| n/a |
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| Name | BDBM285571 |
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| Synonyms: | 3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopro-pyl)imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 44 | US9598421, Example 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10ClF3N4O |
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| Mol. Mass. | 366.725 |
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| SMILES | Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F |
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| Structure | 
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