Ki Summary

Reaction Details

Report a problem with these data

Target

E3 ubiquitin-protein ligase Mdm2

Ligand

BDBM135158

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

1±n/a nM

Citation

Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2

Name:

E3 ubiquitin-protein ligase Mdm2

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

55196.54

Organism:

Homo sapiens (Human)

Description:

Q00987

Residue:

491

Sequence:

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP

BDBM135158

n/a

Name

BDBM135158

Synonyms:

US8846657, 3.50 | US8846657, 3.53 | US8846657, 3.54

Type

Small organic molecule

Emp. Form.

C28H30ClN9O3

Mol. Mass.

576.049

SMILES

C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCCC2c2nonc2C)CC1 |r,wU:1.0,wD:4.4,(7.09,-3.78,;5.6,-3.38,;4.52,-4.47,;3.03,-4.08,;2.63,-2.59,;1.14,-2.19,;.74,-.7,;1.65,.54,;.74,1.79,;-.72,1.31,;-2.05,2.08,;-3.39,1.31,;-3.39,-.23,;-2.05,-1,;-2.05,-2.54,;-.72,-3.31,;-.72,-4.85,;-2.05,-5.62,;-3.39,-4.85,;-4.72,-5.62,;-3.39,-3.31,;-.72,-.23,;-4.72,2.08,;-6.19,1.61,;-7.09,2.85,;-6.19,4.1,;-6.96,5.43,;-4.72,3.62,;3.19,.54,;4.09,-.7,;5.56,-.23,;5.56,1.31,;4.09,1.79,;3.32,3.12,;1.86,3.6,;1.86,5.14,;3.32,5.62,;4.23,4.37,;5.77,4.37,;3.72,-1.5,;5.21,-1.9,)|

Structure