Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM135372 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FRET Assay | ||
IC50 | 1±n/a nM | ||
Citation | Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
| ||
BDBM135372 | |||
n/a | |||
Name | BDBM135372 | ||
Synonyms: | US8846657, 8.8 | US8846657, 8.9 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H26ClF2N7O2 | ||
Mol. Mass. | 566.002 | ||
SMILES | C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(C)(F)c2ccncc2F)CC1 |r,wU:4.4,wD:1.0,(6.49,-5.23,;5.16,-4.46,;5.16,-2.92,;3.82,-2.15,;2.49,-2.92,;1.16,-2.15,;1.16,-.61,;2.06,.64,;1.16,1.88,;-.31,1.41,;-1.64,2.18,;-2.98,1.41,;-2.98,-.13,;-1.64,-.9,;-1.64,-2.44,;-.31,-3.21,;-.31,-4.75,;-1.64,-5.52,;-2.98,-4.75,;-4.31,-5.52,;-2.98,-3.21,;-.31,-.13,;-4.31,2.18,;-5.78,1.7,;-6.68,2.95,;-5.78,4.19,;-6.55,5.52,;-4.31,3.72,;3.6,.64,;3.6,-.9,;4.93,-.13,;4.37,1.97,;3.6,3.3,;4.37,4.64,;5.91,4.64,;6.68,3.3,;5.91,1.97,;6.68,.64,;2.49,-4.46,;3.82,-5.23,)| | ||
Structure |