Ki Summary

Reaction Details

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Target

E3 ubiquitin-protein ligase Mdm2

Ligand

BDBM135406

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

1±n/a nM

Citation

Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2

Name:

E3 ubiquitin-protein ligase Mdm2

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

55196.54

Organism:

Homo sapiens (Human)

Description:

Q00987

Residue:

491

Sequence:

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP

BDBM135406

n/a

Name

BDBM135406

Synonyms:

US8846657, 13.1

Type

Small organic molecule

Emp. Form.

C28H35ClN6O4S

Mol. Mass.

587.133

SMILES

C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)C(=O)NS(C)(=O)=O)N2CCO[C@@H]3CCC[C@@H]23)CC1 |r,wU:1.0,33.36,wD:4.4,37.39,(7.91,-3.1,;6.42,-2.7,;5.33,-3.79,;3.84,-3.39,;3.45,-1.9,;1.96,-1.51,;1.56,-.02,;2.46,1.23,;1.56,2.47,;.09,2,;-1.24,2.77,;-2.57,2,;-2.57,.46,;-1.24,-.31,;-1.24,-1.85,;.09,-2.62,;.09,-4.16,;-1.24,-4.93,;-2.57,-4.16,;-3.91,-4.93,;-2.57,-2.62,;.09,.46,;-3.91,2.77,;-3.91,4.31,;-5.24,2,;-6.57,2.77,;-7.91,2,;-7.34,4.1,;-5.8,4.1,;4,1.23,;4.77,-.11,;6.31,-.11,;7.08,1.23,;6.31,2.56,;6.79,4.03,;5.54,4.93,;4.3,4.03,;4.77,2.56,;4.53,-.81,;6.02,-1.21,)|

Structure