Reaction Details | |||
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Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM135411 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FRET Assay | ||
IC50 | <1±n/a nM | ||
Citation | Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
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BDBM135411 | |||
n/a | |||
Name | BDBM135411 | ||
Synonyms: | US8846657, 14.1 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H27ClF3N9 | ||
Mol. Mass. | 545.99 | ||
SMILES | C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2nnn[nH]2)N2CCC[C@H]2C(F)(F)F)CC1 |r,wU:1.0,wD:4.4,31.36,(7.09,-3.36,;5.6,-2.96,;4.52,-4.05,;3.03,-3.65,;2.63,-2.16,;1.14,-1.76,;.74,-.28,;1.65,.97,;.74,2.22,;-.72,1.74,;-2.05,2.51,;-3.39,1.74,;-3.39,.2,;-2.05,-.57,;-2.05,-2.11,;-.72,-2.88,;-.72,-4.42,;-2.05,-5.19,;-3.39,-4.42,;-4.72,-5.19,;-3.39,-2.88,;-.72,.2,;-4.72,2.51,;-6.19,2.03,;-7.09,3.28,;-6.19,4.53,;-4.72,4.05,;3.19,.97,;4.09,-.28,;5.56,.2,;5.56,1.74,;4.09,2.22,;3.7,3.7,;2.21,4.1,;4.78,4.79,;3.3,5.19,;3.72,-1.07,;5.21,-1.47,)| | ||
Structure |