Reaction Details | |||
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Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM135435 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FRET Assay | ||
IC50 | 1±n/a nM | ||
Citation | Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
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BDBM135435 | |||
n/a | |||
Name | BDBM135435 | ||
Synonyms: | US8846657, 18.3 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H34ClN7O3 | ||
Mol. Mass. | 564.078 | ||
SMILES | C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cc(Cl)cnc4C)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1 |r,wU:4.4,33.37,wD:1.0,37.40,(7.09,-3.69,;5.6,-3.29,;5.21,-1.81,;3.72,-1.41,;2.63,-2.5,;1.14,-2.1,;.74,-.61,;1.65,.64,;.74,1.88,;-.72,1.41,;-2.05,2.18,;-3.39,1.41,;-3.39,-.13,;-2.05,-.9,;-2.05,-2.44,;-.72,-3.21,;-.72,-4.75,;.61,-5.52,;-2.05,-5.52,;-3.39,-4.75,;-3.39,-3.21,;-4.72,-2.44,;-.72,-.13,;-4.72,2.18,;-6.19,1.7,;-7.09,2.95,;-6.19,4.19,;-6.96,5.52,;-4.72,3.72,;3.19,.64,;3.96,-.7,;5.5,-.7,;6.27,.64,;5.5,1.97,;5.97,3.43,;4.73,4.34,;3.48,3.43,;3.96,1.97,;3.03,-3.98,;4.52,-4.38,)| | ||
Structure |