Ki Summary

Reaction Details

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Target

E3 ubiquitin-protein ligase Mdm2

Ligand

BDBM135436

Substrate/Competitor

n/a

Meas. Tech.

FRET Assay

IC50

1±n/a nM

Citation

Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent US8846657 Publication Date 9/30/2014

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2

Name:

E3 ubiquitin-protein ligase Mdm2

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

55196.54

Organism:

Homo sapiens (Human)

Description:

Q00987

Residue:

491

Sequence:

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP

BDBM135436

n/a

Name

BDBM135436

Synonyms:

US8846657, 18.4

Type

Small organic molecule

Emp. Form.

C30H36ClN7O5

Mol. Mass.

610.104

SMILES

C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cc(Cl)cnc4OCCO)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1 |r,wU:36.40,4.4,wD:40.43,1.0,(7.31,-5.23,;5.97,-4.46,;5.97,-2.92,;4.64,-2.15,;3.3,-2.92,;1.97,-2.15,;1.97,-.61,;2.88,.64,;1.97,1.88,;.51,1.41,;-.83,2.18,;-2.16,1.41,;-2.16,-.13,;-.83,-.9,;-.83,-2.44,;.51,-3.21,;.51,-4.75,;1.84,-5.52,;-.83,-5.52,;-2.16,-4.75,;-2.16,-3.21,;-3.49,-2.44,;-4.83,-3.21,;-6.16,-2.44,;-7.5,-3.21,;.51,-.13,;-3.49,2.18,;-4.96,1.7,;-5.86,2.95,;-4.96,4.19,;-5.73,5.52,;-3.49,3.72,;4.42,.64,;5.19,-.7,;6.73,-.7,;7.5,.64,;6.73,1.97,;7.2,3.43,;5.96,4.34,;4.71,3.43,;5.19,1.97,;3.3,-4.46,;4.64,-5.23,)|

Structure