| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM136277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 5±n/a nM |
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| Comments | extracted |
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| Citation |  Heckel, A; Himmelsbach, F; Kley, J; Lehmann-Lintz, T; Redemann, N; Sauer, A; Thomas, L; Wiedenmayer, D; Black, P; Blackaby, W; Linney, I; Austen, M; Danilewicz, J; Schneider, M; Schreiter, K Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions US Patent US8853193 Publication Date 10/7/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
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| Type: | Protein |
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| Mol. Mass.: | 51870.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HBH9 |
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| Residue: | 465 |
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| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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| BDBM136277 |
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| n/a |
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| Name | BDBM136277 |
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| Synonyms: | US8853193, 32.7 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15F2N3O3S |
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| Mol. Mass. | 379.381 |
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| SMILES | CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 |
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| Structure | 
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