Compile Data Set for Download or QSAR

Found 190 hits with Last Name = 'schreiter' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30645 (US8853193, 32-28) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C16H10ClN3O2S3/c17-13-7-8-14(23-13)25(21,22)20-11-5-3-10(4-6-11)15-19-12-2-1-9-18-16(12)24-15/h1-9,20H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136194 (US8853193, 23-3) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(N)=O Show InChI InChI=1S/C17H15F3N4O2S/c1-8-13-16(22-7-23-17(13)27-14(8)15(21)25)24-11-3-2-9(20)4-12(11)26-10(5-18)6-19/h2-4,7,10H,5-6H2,1H3,(H2,21,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM98036 (US8486953, 19) Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136277 (US8853193, 32.7) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H15F2N3O3S/c1-8(6-18)25-12-5-10(19)3-4-11(12)22-15-13-9(2)14(17(23)24)26-16(13)21-7-20-15/h3-5,7-8H,6H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM98040 (US8486953, 53) Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro kinase assay using human Mnk1 and Mnk2.				US Patent US8486953 (2013) BindingDB Entry DOI: 10.7270/Q2TM78R3
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136193 (US8853193, 23-2) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(O)=O Show InChI InChI=1S/C17H14F3N3O3S/c1-8-13-15(21-7-22-16(13)27-14(8)17(24)25)23-11-3-2-9(20)4-12(11)26-10(5-18)6-19/h2-4,7,10H,5-6H2,1H3,(H,24,25)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136283 (US8853193, 32-44) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12 Show InChI InChI=1S/C24H29F2N5O2S/c1-15(13-25)33-19-12-17(26)6-7-18(19)30-22-20-16(2)21(34-24(20)29-14-28-22)23(32)27-8-5-11-31-9-3-4-10-31/h6-7,12,14-15H,3-5,8-11,13H2,1-2H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM98040 (US8486953, 53) Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30641 (US8853193, 32-26) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 Show InChI InChI=1S/C28H23ClN4O2/c1-18-15-20(19(2)33(18)22-13-11-21(29)12-14-22)16-30-31-27(34)17-32-25-9-5-3-7-23(25)28(35)24-8-4-6-10-26(24)32/h3-16H,17H2,1-2H3,(H,31,34)/b30-16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30642 (US8853193, 32-27) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 Show InChI InChI=1S/C16H12N2O2/c19-15-11-12-16(20)18(15)17(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-12H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136200 (US8853193, 23-9) Show SMILES CN(C)CC#CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C23H24F3N5O2S/c1-14-19-21(30-17-7-6-15(26)10-18(17)33-16(11-24)12-25)28-13-29-23(19)34-20(14)22(32)27-8-4-5-9-31(2)3/h6-7,10,13,16H,8-9,11-12H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136201 (US8853193, 23-10) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCCN1CCCC1 Show InChI InChI=1S/C24H28F3N5O2S/c1-15-20-22(31-18-6-5-16(27)11-19(18)34-17(12-25)13-26)29-14-30-24(20)35-21(15)23(33)28-7-4-10-32-8-2-3-9-32/h5-6,11,14,17H,2-4,7-10,12-13H2,1H3,(H,28,33)(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136202 (US8853193, 24) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C18H17F3N4O4S2/c1-9-14-16(22-8-23-18(14)30-15(9)17(26)25-31(2,27)28)24-12-4-3-10(21)5-13(12)29-11(6-19)7-20/h3-5,8,11H,6-7H2,1-2H3,(H,25,26)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136262 (US8853193, 53) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCC#N Show InChI InChI=1S/C20H16F2N6O2S/c1-11-16-18(26-10-27-20(16)31-17(11)19(29)25-5-4-23)28-14-3-2-12(9-24)6-15(14)30-13(7-21)8-22/h2-3,6,10,13H,5,7-8H2,1H3,(H,25,29)(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30636 (US8853193, 32-21) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12)C(N)=O Show InChI InChI=1S/C16H12N2O2/c19-15-11-12-16(20)18(15)17(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-12H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM31312 (US8853193, 32-37) Show SMILES COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C18H19FN4O3S/c1-9(7-25-3)26-13-6-11(19)4-5-12(13)23-17-14-10(2)15(16(20)24)27-18(14)22-8-21-17/h4-6,8-9H,7H2,1-3H3,(H2,20,24)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136175 (US8853193, 16-2) Show SMILES CC(CCN)Oc1ncccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H19N5O3S/c1-9(5-6-18)25-15-11(4-3-7-19-15)22-14-12-10(2)13(17(23)24)26-16(12)21-8-20-14/h3-4,7-9H,5-6,18H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136195 (US8853193, 23-4) Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C18H17F3N4O2S/c1-9-14-16(23-8-24-18(14)28-15(9)17(26)22-2)25-12-4-3-10(21)5-13(12)27-11(6-19)7-20/h3-5,8,11H,6-7H2,1-2H3,(H,22,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136199 (US8853193, 23-8) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCO Show InChI InChI=1S/C19H19F3N4O3S/c1-10-15-17(24-9-25-19(15)30-16(10)18(28)23-4-5-27)26-13-3-2-11(22)6-14(13)29-12(7-20)8-21/h2-3,6,9,12,27H,4-5,7-8H2,1H3,(H,23,28)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136275 (US8853193, 32-5) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12)C(O)=O Show InChI InChI=1S/C18H14F3N3O3S/c1-8-13-15(22-7-23-16(13)28-14(8)17(25)26)24-11-3-2-10(19)4-12(11)27-6-9-5-18(9,20)21/h2-4,7,9H,5-6H2,1H3,(H,25,26)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136258 (US8853193, 49) Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C Show InChI InChI=1S/C23H26F2N6O2S/c1-14-19-21(30-17-6-5-15(12-26)9-18(17)33-16(10-24)11-25)28-13-29-23(19)34-20(14)22(32)27-7-4-8-31(2)3/h5-6,9,13,16H,4,7-8,10-11H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136197 (US8853193, 23-6) Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C22H26F3N5O2S/c1-13-18-20(29-16-6-5-14(25)9-17(16)32-15(10-23)11-24)27-12-28-22(18)33-19(13)21(31)26-7-4-8-30(2)3/h5-6,9,12,15H,4,7-8,10-11H2,1-3H3,(H,26,31)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136260 (US8853193, 51) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCO Show InChI InChI=1S/C20H19F2N5O3S/c1-11-16-18(25-10-26-20(16)31-17(11)19(29)24-4-5-28)27-14-3-2-12(9-23)6-15(14)30-13(7-21)8-22/h2-3,6,10,13,28H,4-5,7-8H2,1H3,(H,24,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136185 (US8853193, 21-3) Show SMILES CC(Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C(F)(F)F Show InChI InChI=1S/C16H14F3N5O2S/c1-7-10-13(22-6-23-15(10)27-11(7)12(20)25)24-9-4-3-5-21-14(9)26-8(2)16(17,18)19/h3-6,8H,1-2H3,(H2,20,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136219 (US8853193, 31-5) Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C19H20FN5O3S/c1-4-22-18(27)10(3)28-13-7-11(20)5-6-12(13)25-17-14-9(2)15(16(21)26)29-19(14)24-8-23-17/h5-8,10H,4H2,1-3H3,(H2,21,26)(H,22,27)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136284 (US8853193, 32-45) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC3CCN(C)CC3)c(C)c12 Show InChI InChI=1S/C23H27F2N5O2S/c1-13(11-24)32-18-10-15(25)4-5-17(18)29-21-19-14(2)20(33-23(19)27-12-26-21)22(31)28-16-6-8-30(3)9-7-16/h4-5,10,12-13,16H,6-9,11H2,1-3H3,(H,28,31)(H,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136263 (US8853193, 54) Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C#N Show InChI InChI=1S/C17H14FN5O2S/c1-8(6-19)25-12-5-10(18)3-4-11(12)23-16-13-9(2)14(15(20)24)26-17(13)22-7-21-16/h3-5,7-8H,1-2H3,(H2,20,24)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM32187 (US8853193, 32-42) Show SMILES CC(CC(F)(F)F)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12 Show InChI InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136188 (US8853193, 21-6) Show SMILES CNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c2c1C Show InChI InChI=1S/C17H16F3N5O2S/c1-8-11-13(23-7-24-16(11)28-12(8)14(26)21-3)25-10-5-4-6-22-15(10)27-9(2)17(18,19)20/h4-7,9H,1-3H3,(H,21,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136203 (US8853193, 25) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)N[C@@H]1C[C@H]1N |r| Show InChI InChI=1S/C20H20F3N5O2S/c1-9-16-18(27-13-3-2-10(23)4-15(13)30-11(6-21)7-22)25-8-26-20(16)31-17(9)19(29)28-14-5-12(14)24/h2-4,8,11-12,14H,5-7,24H2,1H3,(H,28,29)(H,25,26,27)/t12-,14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136281 (US8853193, 32-12) Show SMILES CC(F)COc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H15F2N3O3S/c1-8(18)6-25-12-5-10(19)3-4-11(12)22-15-13-9(2)14(17(23)24)26-16(13)21-7-20-15/h3-5,7-8H,6H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136282 (US8853193, 32-43) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCC3CCN(C)C3)c(C)c12 Show InChI InChI=1S/C24H29F2N5O2S/c1-14(11-25)33-19-10-17(26)4-5-18(19)30-22-20-15(2)21(34-24(20)29-13-28-22)23(32)27-8-6-16-7-9-31(3)12-16/h4-5,10,13-14,16H,6-9,11-12H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136227 (US8853193, 35) Show SMILES COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C Show InChI InChI=1S/C17H18N4O3S/c1-9(2)24-15-11(6-5-7-18-15)21-14-12-10(3)13(17(22)23-4)25-16(12)20-8-19-14/h5-9H,1-4H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136257 (US8853193, 48) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCCN1CCCC1 Show InChI InChI=1S/C25H28F2N6O2S/c1-16-21-23(32-19-6-5-17(14-28)11-20(19)35-18(12-26)13-27)30-15-31-25(21)36-22(16)24(34)29-7-4-10-33-8-2-3-9-33/h5-6,11,15,18H,2-4,7-10,12-13H2,1H3,(H,29,34)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30638 (US8853193, 32-23 | US8853193, 32-25) Show SMILES COCC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 Show InChI InChI=1S/C17H17NO2.ClH/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;/h2-6,13,19-20H,7-9H2,1H3;1H/t13-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM31093 (4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...) Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13| Show InChI InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136196 (US8853193, 23-5) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)N[C@@H]1C[C@H]1NC(=O)OC(C)(C)C |r| Show InChI InChI=1S/C25H28F3N5O4S/c1-12-19-21(31-15-6-5-13(28)7-18(15)36-14(9-26)10-27)29-11-30-23(19)38-20(12)22(34)32-16-8-17(16)33-24(35)37-25(2,3)4/h5-7,11,14,16-17H,8-10H2,1-4H3,(H,32,34)(H,33,35)(H,29,30,31)/t16-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136220 (US8853193, 31-6) Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC)c(C)c12 Show InChI InChI=1S/C20H22FN5O3S/c1-5-23-18(27)11(3)29-14-8-12(21)6-7-13(14)26-17-15-10(2)16(19(28)22-4)30-20(15)25-9-24-17/h6-9,11H,5H2,1-4H3,(H,22,28)(H,23,27)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136274 (US8853193, 32-4) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12)C(O)=O Show InChI InChI=1S/C16H12F3N3O3S/c1-7-12-14(20-6-21-15(12)26-13(7)16(23)24)22-9-3-2-8(17)4-10(9)25-5-11(18)19/h2-4,6,11H,5H2,1H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136278 (US8853193, 32-9) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCCO)c12)C(O)=O Show InChI InChI=1S/C16H14FN3O4S/c1-8-12-14(18-7-19-15(12)25-13(8)16(22)23)20-10-3-2-9(17)6-11(10)24-5-4-21/h2-3,6-7,21H,4-5H2,1H3,(H,22,23)(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136259 (US8853193, 50) Show SMILES CN1CCC(CC1)NC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C Show InChI InChI=1S/C24H26F2N6O2S/c1-14-20-22(31-18-4-3-15(12-27)9-19(18)34-17(10-25)11-26)28-13-29-24(20)35-21(14)23(33)30-16-5-7-32(2)8-6-16/h3-4,9,13,16-17H,5-8,10-11H2,1-2H3,(H,30,33)(H,28,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136163 (US8853193, 7) Show SMILES CC(CN)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H17FN4O3S/c1-8(6-19)25-12-5-10(18)3-4-11(12)22-15-13-9(2)14(17(23)24)26-16(13)21-7-20-15/h3-5,7-8H,6,19H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136280 (US8853193, 32-11) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCCC(F)(F)F)c12)C(O)=O Show InChI InChI=1S/C17H13F4N3O3S/c1-8-12-14(22-7-23-15(12)28-13(8)16(25)26)24-10-3-2-9(18)6-11(10)27-5-4-17(19,20)21/h2-3,6-7H,4-5H2,1H3,(H,25,26)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136247 (US8853193, 36-19) Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC#CCN)c(C)c12 Show InChI InChI=1S/C20H22N6O2S/c1-12(2)28-19-14(7-6-10-23-19)26-17-15-13(3)16(29-20(15)25-11-24-17)18(27)22-9-5-4-8-21/h6-7,10-12H,8-9,21H2,1-3H3,(H,22,27)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136184 (US8853193, 21-2) Show SMILES CC(Oc1ncccc1Nc1ncnc2sc(C(O)=O)c(C)c12)C(F)(F)F Show InChI InChI=1S/C16H13F3N4O3S/c1-7-10-12(21-6-22-14(10)27-11(7)15(24)25)23-9-4-3-5-20-13(9)26-8(2)16(17,18)19/h3-6,8H,1-2H3,(H,24,25)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136226 (US8853193, 34-4) Show SMILES Cc1c(sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c12)C(N)=O Show InChI InChI=1S/C17H15F2N5O2S/c1-8-11-14(22-7-23-16(11)27-12(8)13(20)25)24-10-3-2-4-21-15(10)26-6-9-5-17(9,18)19/h2-4,7,9H,5-6H2,1H3,(H2,20,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30632 (US8853193, 32-17) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12)C(N)=O Show InChI InChI=1S/C17H14N2O2/c1-19-15-10-6-5-9-13(15)16(20)14(17(19)21)11-18-12-7-3-2-4-8-12/h2-11,18H,1H3/b14-11+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136224 (US8853193, 33-4) Show SMILES Cc1c(sc2ncnc(Nc3cccnc3OCC3(CC#N)CC3)c12)C(N)=O Show InChI InChI=1S/C19H18N6O2S/c1-11-13-16(23-10-24-18(13)28-14(11)15(21)26)25-12-3-2-8-22-17(12)27-9-19(4-5-19)6-7-20/h2-3,8,10H,4-6,9H2,1H3,(H2,21,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136198 (US8853193, 23-7) Show SMILES CN(C)CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C21H24F3N5O2S/c1-12-17-19(28-15-5-4-13(24)8-16(15)31-14(9-22)10-23)26-11-27-21(17)32-18(12)20(30)25-6-7-29(2)3/h4-5,8,11,14H,6-7,9-10H2,1-3H3,(H,25,30)(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136272 (US8853193, 63) Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12)C#N Show InChI InChI=1S/C22H25FN6O2S/c1-13(11-24)31-17-10-15(23)6-7-16(17)28-20-18-14(2)19(32-22(18)27-12-26-20)21(30)25-8-5-9-29(3)4/h6-7,10,12-13H,5,8-9H2,1-4H3,(H,25,30)(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair

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