Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 2' and Ligand = 'BDBM136259'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136259 (US8853193, 50) Show SMILES CN1CCC(CC1)NC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C Show InChI InChI=1S/C24H26F2N6O2S/c1-14-20-22(31-18-4-3-15(12-27)9-19(18)34-17(10-25)11-26)28-13-29-24(20)35-21(14)23(33)30-16-5-7-32(2)8-6-16/h3-4,9,13,16-17H,5-8,10-11H2,1-2H3,(H,30,33)(H,28,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
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