| Reaction Details |
|---|
 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Ligand | BDBM138075 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | 17±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Motomura, T; Nagamori, H; Suzawa, K; Ito, H; Morita, T; Kobayashi, S; Shinkai, H Fluorene compound and pharmaceutical use thereof US Patent US8871934 Publication Date 10/28/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46153.78 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15119 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
|
|
|
|---|
| BDBM138075 |
|---|
| n/a |
|---|
| Name | BDBM138075 |
|---|
| Synonyms: | US8871934, 668 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H25F3N2O2 |
|---|
| Mol. Mass. | 442.4734 |
|---|
| SMILES | OCc1cc(cc2c1-c1ccccc1C2(O)C(F)(F)F)-c1cnn(CC2CCCCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
