| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
|---|
| Ligand | BDBM138202 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Inhibition Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Choi, J; Hwang, H; Lee, E; Lee, J; Song, H; Kim, SW; Kim, J; Koh, JS; Lee, T; Choi, Y; Han, I; Lee, J; Lee, IY; Jung, DS Substituted pyrimidine compounds and their use as SYK inhibitors US Patent US8871778 Publication Date 10/28/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK |
|---|
| Name: | Tyrosine-protein kinase SYK |
|---|
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 72079.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43405 |
|---|
| Residue: | 635 |
|---|
| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM138202 |
|---|
| n/a |
|---|
| Name | BDBM138202 |
|---|
| Synonyms: | US8871778, 152 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25N7O2 |
|---|
| Mol. Mass. | 431.4903 |
|---|
| SMILES | CC(=O)c1cn(C)c2ccc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
