Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM138208 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Inhibition Assay |
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Temperature | 298.15±n/a K |
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IC50 | 2.1±n/a nM |
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Comments | extracted |
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Citation | Choi, J; Hwang, H; Lee, E; Lee, J; Song, H; Kim, SW; Kim, J; Koh, JS; Lee, T; Choi, Y; Han, I; Lee, J; Lee, IY; Jung, DS Substituted pyrimidine compounds and their use as SYK inhibitors US Patent US8871778 Publication Date 10/28/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM138208 |
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n/a |
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Name | BDBM138208 |
Synonyms: | US8871778, 180 |
Type | Small organic molecule |
Emp. Form. | C24H24N8OS |
Mol. Mass. | 472.565 |
SMILES | Cc1nn(cc1CN1CC(O)C1)-c1ccnc(Nc2ccc3n(C)cc(-c4nccs4)c3c2)n1 |
Structure |
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