| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 1 |
|---|
| Ligand | BDBM138342 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 80±n/a nM |
|---|
| Citation |  Papeo, GM; Anatolievna Busel, A; Khvat, A; Krasavin, MY; Forte, B; Zuccotto, F 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors US Patent US8877944 Publication Date 11/4/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase 1 |
|---|
| Name: | Poly [ADP-ribose] polymerase 1 |
|---|
| Synonyms: | Adprp | Adprt | Adprt1 | PARP1_MOUSE | Parp1 | Poly [ADP-ribose] polymerase 1 (Parp1) | Poly [ADP-ribose] polymerase-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 113131.74 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_159828 |
|---|
| Residue: | 1013 |
|---|
| Sequence: | MAEASERLYRVQYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GQSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFAAEYAKS
NRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQ
LKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSRKETDKYSKLEKALKA
QNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSG
QLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
SSAPITVHWPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLT
GSANKASLCISIKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQDLLSAHSLSP
WGAEVKAEPGEVVAPRGKSAAPSKKSKGCFKEEGVNKSEKRMKLTLKGGAAVDPDSGLEH
SAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRLGTVIGSNKL
EQMPSKEEAVEQFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGT
KSKLPKPVQELVGMIFDVDSMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQPVS
QGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGG
SDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIER
EGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMV
SKSANYCHTSQGDPIGLIMLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSAS
ITLEGVEVPLGTGIPSGVNDTALLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
|
|
|
|---|
| BDBM138342 |
|---|
| n/a |
|---|
| Name | BDBM138342 |
|---|
| Synonyms: | US8877944, 47 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O2 |
|---|
| Mol. Mass. | 377.4794 |
|---|
| SMILES | Cc1ccc(CN2CCC(CN3Cc4cccc(C(N)=O)c4C3=O)CC2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
