Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
---|
Ligand | BDBM285698 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Calcineurin Phosphatase (CaN) Assay |
---|
IC50 | 377±n/a nM |
---|
Citation | Pettit, SN; Jones, AD; Frydrych, CS; Thomas, AJ; Garst, ME Cyclosporins modified on the MeBmt sidechain by heterocyclic rings US Patent US10077289 Publication Date 9/18/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
---|
Name: | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
Synonyms: | CALNA3 | CAM-PRP catalytic subunit | CNA3 | Calcineurin, testis-specific catalytic subunit | Calmodulin-dependent calcineurin A subunit gamma isoform | PP2BC_HUMAN | PPP3CC |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58133.25 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 512 |
Sequence: | MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKI
INDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGY
FSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDC
LPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKT
LEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLIT
IFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEM
LVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGL
TPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPR
KDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
|
|
|
BDBM285698 |
---|
n/a |
---|
Name | BDBM285698 |
Synonyms: | US10077289, Compound 6 | [(2S,3R,4R)-3-Hydroxy-5-(1-(3-hydroxypropyl)-1H-imidazol-2-yl)-4-methyl-2-(methylamino) pentanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A |
Type | Small organic molecule |
Emp. Form. | C66H117N13O13 |
Mol. Mass. | 1300.7145 |
SMILES | CC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)Cc2nccn2CCCO)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C |r| |
Structure |
|