| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
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| Ligand | BDBM285716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcineurin Phosphatase (CaN) Assay |
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| IC50 | 650±n/a nM |
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| Citation |  Pettit, SN; Jones, AD; Frydrych, CS; Thomas, AJ; Garst, ME Cyclosporins modified on the MeBmt sidechain by heterocyclic rings US Patent US10077289 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
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| Name: | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
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| Synonyms: | CALNA3 | CAM-PRP catalytic subunit | CNA3 | Calcineurin, testis-specific catalytic subunit | Calmodulin-dependent calcineurin A subunit gamma isoform | PP2BC_HUMAN | PPP3CC |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58133.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 512 |
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| Sequence: | MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKI
INDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGY
FSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDC
LPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKT
LEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLIT
IFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEM
LVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGL
TPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPR
KDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
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| BDBM285716 |
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| n/a |
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| Name | BDBM285716 |
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| Synonyms: | US10077289, Compound 24 | [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(oxazolin-2-yl)-heptanoic acid]1 cyclosporin A |
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| Type | Small organic molecule |
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| Emp. Form. | C65H114N12O13 |
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| Mol. Mass. | 1271.6733 |
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| SMILES | CC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)CCCc2ncco2)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C |r| |
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| Structure | 
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