| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM285769 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | RORgammat (full-length human) Reporter Assay A |
|---|
| IC50 | 4.60±n/a nM |
|---|
| Citation |  Goldberg, S; Steeneck, C; Gege, C; Kinzel, O; Kleymann, G; Hoffmann, T; Fourie, AM; Xue, X Thiazoles as modulators of RORγt US Patent US10080744 Publication Date 9/25/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 58218.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51449 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
|
|
|
|---|
| BDBM285769 |
|---|
| n/a |
|---|
| Name | BDBM285769 |
|---|
| Synonyms: | US10080744, Example 3/36 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H31F6N3O4S |
|---|
| Mol. Mass. | 619.619 |
|---|
| SMILES | CC(C)(C)c1cc(cc(c1)C(O)(C(F)(F)F)C(F)(F)F)-c1sc(nc1CC1CCC1)-c1nnc(CC(C)(C)C(O)=O)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
