| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM140081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 10±n/a nM |
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| Comments | extracted |
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| Citation |  Inoue, H; Murafuji, H; Hayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM140081 |
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| n/a |
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| Name | BDBM140081 |
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| Synonyms: | US8901315, 155 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30FN5OS |
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| Mol. Mass. | 455.591 |
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| SMILES | CN1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1F |
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| Structure | 
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