Reaction Details | |||
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Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
Ligand | BDBM140140 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.5±n/a | ||
Temperature | 277.15±n/a K | ||
IC50 | 14±n/a nM | ||
Comments | extracted | ||
Citation | Inoue, H; Murafuji, H; Hayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | |||
Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 55514.96 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13946 | ||
Residue: | 482 | ||
Sequence: |
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BDBM140140 | |||
n/a | |||
Name | BDBM140140 | ||
Synonyms: | US8901315, 273 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30N4O3S | ||
Mol. Mass. | 442.574 | ||
SMILES | Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O |r,wU:18.20,wD:21.27,(-6.96,3.48,;-6.19,2.14,;-7.1,.9,;-6.19,-.35,;-6.59,-1.84,;-8.08,-2.23,;-8.48,-3.72,;-7.39,-4.81,;-5.9,-4.41,;-5.5,-2.92,;-4.73,.13,;-3.27,-.35,;-2.36,.9,;-3.27,2.14,;-4.73,1.67,;-.82,.9,;-.05,-.44,;-.05,2.23,;1.49,2.23,;2.26,3.56,;3.8,3.56,;4.57,2.23,;3.8,.9,;2.26,.9,;6.11,2.23,;7.01,.99,;6.24,-.35,;8.48,1.46,;8.48,3,;7.01,3.48,;6.24,4.81,)| | ||
Structure |